Global Journal of Digestive Diseases

Upper Limit of Normal Serum Alanine Transaminase ALT and Correlation with Gender and BMI

Alanine transaminase ALT and aspartate transaminase AST are considered as important marker for hepatocellular membrane damage, ALT is more specific to hepatocellular injury than AST, once transaminases rise by 1-4% of the general population; it is classified according to upper limit of normal ULN to Mild when rise up to (2-3) times of ULN such as in celiac disease, thyroid disease (hypo or hyperthyroidism), adrenal insufficiency, systemic infections, etc. Moderate when rise from 2-3 times to 20 times of ULN such as in the early stages of viral hepatitis, congestive hepatopathy and non- alcoholic fatty live disease NAFLD that accounts the most common cause of mild to moderate elevation ALT in asymptomatic patients. Severe when rise more than 20 times of UNL such as in acute viral hepatitis, ischemic hepatitis and drug induced hepatitis.

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Author(s):

Zyad Alali

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