There is a vast ecology of microbes that are necessary for health in intestinal tract, but this tract also have the potential to contribute to the development of diseases by different mechanisms. Intestinal epithelial barrier function disturbances or defect in intrinsic immune, can lead to increased antigens uptake that stimulate the immune system. So inflammatory response occurred [1-4]. Intestinal microbes may cause widespread diseases so their interactions with the host are the subject of recently researches. Planned manipulation of the intestinal microflora with a therapeutic intention are of the main parts of these researches. The greatest experience has been in the inflammatory bowel diseases included ulcerative colitis and Crohn disease, although clinical trials in several other conditions are emerging.
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