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Does High Level of Uric Acid Lead to Nonalcoholic Fatty Liver Disease?

Abstract Nonalcoholic fatty liver disease (NAFLD) was considered as a hepatic manifestation of metabolic syndrome. Uric acid is the final metabolite of purine compounds in human. Purine metabolic disorders lead to hyperuricemia, which has a close relationship with NAFLD. Recent studies have shown that uric acid can induce NAFLD by stimulating endoplasmic reticulum stress, oxidative stress and insulin resistance. However, the relationship reported by many studies between NAFLD and hyperuricemia remains controversial. What role of UA plays in NAFLD needs further explored. This paper reviews the relationship between hyperuricemia and NAFLD in clinic and experimental animals, as well as its potential underlying mechanism.


Chunlei Zhang, Haiyan Song, Lili Yang, Yang Liu and Guang Ji

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