Purpose: We have projected to evaluate the potency of methanol extract of Albizia procera (MEAP) leaves against diarrheal model.
Methods: The leave extract of A. procera (100 and 200 mg/kg body weight) was administered by oral route to different groups of mice (each group containing three mice) to justify the action extract against castor oil and MgSO4 induced diarrhea model. Loperamide (5 mg/kg) was used as positive control or standard. The effect of the extract on MgSO4 and castor oil-induced intestinal fluid accumulation (enteropooling) was assessed.
Results: Both the doses of 100 and 200 mg/kg body weight was found substantial (p < 0.01) in controlling diarrheal activity. The extract at the dose of 200 mg/kg showed such an effect comparable to that of standards effect. No mortality or visible signs of general weakness were observed in the animals following the oral administration of extract up to a dose of 1000 mg/kg.
Mohammed Forhad hossain, Jabed Hossain, Mahfujur Rahman, Mohammad Ibtida-Bin-Shahid, Manzurul Quadar, Kazi Omar Faruq, Shofiul Azam, Shadman Rahman, Md. Mahdee Hasan
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